We describe here the functional implications of an increase in IgG binding to the neonatal Fc receptor We have defined in a systematic fashion the relationship between enhanced FcRn binding of a humanized antirespiratory sincytial virus (RSV) monoclonal antibody (MEDI524) and the corresponding biological consequences in cynomolgus monkeys The triple mutationHere, we identify the neonatal Fc receptor (FcRn) as a panechovirus receptor We show that loss of expression of FcRn or its binding partner beta 2 microglobulin (β2M) renders cells resistant to infection by a panel of echoviruses at the stage of virus attachment, and that a blocking antibody to β2M inhibits echovirus infection in cell lines and in primary human intestinal epithelial cells11/27/13 · The neonatal Fc receptor (FcRn) mediates immunoglobulin G (IgG) transport across polarized epithelial barriers (7, 8) It was discovered as the receptor in the neonatal intestine that transports IgG in breast milk from mother to offspring
A Comprehensive Review Of The Neonatal Fc Receptor And Its Application In Drug Delivery Sciencedirect